EVOLUTIONARY AND GENETIC RECOMBINATION ANALYSES OF COXSACKIEVIRUS A6 VARIANTS ASSOCIATED WITH HAND, FOOT, AND MOUTH DISEASE OUTBREAKS IN THAILAND BETWEEN 2019 AND 2022

Evolutionary and Genetic Recombination Analyses of Coxsackievirus A6 Variants Associated with Hand, Foot, and Mouth Disease Outbreaks in Thailand between 2019 and 2022

Coxsackievirus (CV)-A6 infections cause hand, foot, and mouth disease (HFMD) in children and adults.Despite the serious public health threat presented by CV-A6 infections, our understanding of the mechanisms by which new CV-A6 strains emerge remains limited.This study investigated the molecular epidemiological trends, evolutionary dynamics, and rec

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Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity

A structure-guided modelling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl ring of amide-linked bipyrazole moieties, aiming at attaining better anti-inflammatory effect with a good safety profile.Bromo, fluoro, nitro, and methyl groups were revealed Patio Sectional to

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Determinants of Tourism Demand Using Machine Learning Techniques

The purpose of the current study was to determine factors affecting tourism demand using machine learning techniques.The results of Leather Conditioner different linear regression and random forest models on both the train and test sets were compared using RMSE and R2.The random forest model outperformed the linear regression model on both the trai

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The Adversities of Secondary Parenting faced by the Older Persons in Alice, South Africa: Social Work implications

The phenomenon of secondary parenting, in some contexts, presents both a pernicious and a perfidious experience to older persons who should be enjoying their sunset years with some level of relief and respite.The study aimed to explore the adversities experienced by the older persons linked to Lavela Old Age Centre, in Alice South Africa.The study

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